Guide Epidemiology of Human Congenital Malformations

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London: Butterworths; Congenital malformation: a report of a report of a study of series of consecutive births in 24 centres. Bull W0rld Health Organ. Congenital malformation-a retrospective study of 10, cases. Indian J Pediatr. Congenital malformations in newborn. Indian Pediatr.


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Indexing metadata. How to cite item. Finding References. Email this article Login required. Incidence and distribution of congenital malformations in newborns:a hospital based study. Abstract Background: It is considered that the congenital disorders are not a public health problem among the developing countries, however, over the recent years, they are actually experiencing a transition in the epidemiology like significant reduction in infant mortality rates, decline in infections and malnutrition and also a relative rise in morbidity as well as mortality due to the congenital malformations.

View via Publisher. Save to Library. Create Alert. Similar Papers. Figures, Tables, and Topics from this paper. Figures and Tables. Citations Publications citing this paper. Fetal effects of maternal drug treatment. Although the overall prevalence of congenital anomalies for European centres in the EUROCAT network declined from per 10 in to per 10 in , registries in France, Belgium, Malta, Switzerland, Spain, and Italy reported increasing rates over time.

British including Glasgow , Irish, Dutch, and Danish registers reported a declining trend. The main finding of the present study was that Glasgow experienced an overall downward trend in the prevalence of congenital anomalies as a whole from to The pattern was not, however, consistent across all categories: there was a significant increase in the prevalence of chromosomal anomalies, notably Down's syndrome. All other groups of anomalies experienced an overall downward secular trend.

Neural tube defect is one of the most frequent types of defects and one of the leading causes of the fetal and infant mortality caused by congenital anomalies around the world. Historically, Glasgow had a relatively high prevalence compared to other parts of Europe, 13 but the recent steep decline in prevalence suggests that this may no longer be the case. In seeking to explain geographical and secular trends, potential underlying contributing factors should be considered.

Case ascertainment methods, including data collection, sources of information, and type of notification of fetal death, may vary in place and time.

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Although we cannot rule out the impact of these factors in our data, we suspect they are of minor importance given the relative methodological consistency with which the Glasgow data were collected and analysed over time. Improving antenatal screening and prenatal diagnosis may, however, have increased the ascertainment rate and therefore the prevalence of some anomalies. Demographic and environmental factors 14, 15 may influence the prevalence of anomalies. Maternal age is strongly associated with the prevalence of chromosomal anomalies, especially Down's syndrome, and the rising proportion of older mothers is likely to have contributed substantially to the upward trend in the prevalence of this anomaly in Glasgow.

Of the environmental factors, much attention has recently focused on the role of preconceptional vitamin supplementation especially folic acid for the primary prevention of congenital anomalies, particularly neural tube defects. As yet, however, there is little evidence of any major change in secular trend of neural tube defects attributable to folate supplementation.

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Finally, the particular pattern of prevalence, and the increasing trend of some groups of anomalies in Glasgow, reported by a register with good ascertainment and validated data, may give rise to speculation that there may be some specific local risk or causal factors for those anomalies. Although some studies have investigated this possibility, there is little supportive evidence. Macdonell and colleagues, 18 for example, reported no relation between high concentrations of lead in domestic water supplies and neural tube defects, and Eizaguirre-Garcia and colleagues 19 found no correlation between soil pollution with chromium waste and an increased risk of congenital anomalies.

In conclusion, this descriptive epidemiological study of congenital anomalies in Glasgow suggests that, despite a considerable decline in the prevalence of some types of congenital anomaly, around 2.

The apparently contrasting risk of congenital anomaly in Glasgow compared to other European centres and the declining prevalence of most types of anomaly remain largely unexplained. You will be able to get a quick price and instant permission to reuse the content in many different ways. Skip to main content.

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Epidemiology of Human Congenital Malformations

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Prevalence and secular trend of congenital anomalies in Glasgow, UK. Abstract Aim: To describe the epidemiology of congenital anomalies in Glasgow with special reference to secular trends. Statistics from Altmetric. METHODS Congenital anomalies were defined as structural defects, chromosomal abnormalities, inborn errors of metabolism, and hereditary disease diagnosed before, at, or after birth.